WHY DO THE HUMAN CELLS USE AMP ACTIVATORS
Posted on January 18 2021
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs.
The current studies evaluated the transcriptome responses in skeletal muscle, heart, liver and white and brown adipose to novel small molecule activators of AMPK compared to that of exercise.
ATP (adenosine triphosphate) is the main source of energy for most cellular processes. ATP is the energy currency of the cell and is used to power a variety of cellular reactions. The building blocks of ATP, as we know are carbon, nitrogen, hydrogen, oxygen and phosphorus. Most of the ATP in cells is produced by the enzyme ATP synthase, which converts ADP and phosphate to ATP. It is well known that AMP is produced during ATP synthesis.
ATP finds use in several cellular processes. Some important functions of ATP in the cell are briefly discussed below:
- Active Transport - ATP plays a critical role in the transport of macromolecules such as proteins and lipids into and out of the cell
- Cell Signalling - ATP has key functions both in intracellular and extracellular signalling
- Structural Maintenance - ATP plays a very important role in preserving the structure of the cell by helping the assembly of the cytoskeletal elements
- Muscle contraction - ATP is critical for the contraction of muscles as it binds to myosin to provide the energy and facilitate its binding to actin to form a cross-bridge
ATP is an intricate molecule that serves as an energy packet for thousands of reactions that take place in the cells of most organisms. Apart from humans, microorganisms also rely on ATP for their energy requirements.
ATP is a highly efficient molecular machine with a rapid turnover of energy that makes it suitable to meet the changing energy demands of the body. An ATP molecule is over 500 atomic mass units (AMUs).
Activation of AMPK has long been regarded as one of the crucial signaling nodes responsible for the transcriptional response to exercise. AMPK is acutely activated via phosphorylation in response to exercise
Why exercise is good for the human body!
Even a single session of exercise, especially of moderate to high intensity, can improve insulin sensitivity and glucose homeostasis for a short period of time. Because long- and short-acting AMPK activators do have similar acute effects to stimulate glucose uptake and fat oxidation, a similar pattern of results might have been observed if a short-acting AMPK activator had been administered immediately following exercise, but with an important caveat that respective effects on tissue glycogen may well differ, as earlier shown during resting conditions
Adenosine Monophosphate is a key component of the metabolic process and ATP production. It plays a vital role in ATP production and creates fuel for cellular energy and fat metabolism. The key ingredients of the product are Adenosine Monophosphate (AMP) - research has found that increased levels of AMP can induce an increase in the activity of AMPk which works to switch cells from ATP consumption to ATP production.
AMP Improves Fat and Carbohydrate Metabolism and Increases Cellular Energy in the body and that is exactly why we at Dr. Restivo propose AMP Activator to our patients in weight loss programs and for Chronic fatigue syndrome.
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